【New Research】Oligo Fucoidan Improves Diabetes-Induced Renal Fibrosis via Activation of Sirt-1, GLP-

Congratulations to Professor Tz-Chong Chou of the Clinical Medicine Research Center of Cathay Pacific Hospital for his scientific research results published in the international scientific journal [Nutrients]. Oligo Fucoidan used in this research was provided by Hi-Q Marine Biotech. Hi-Q has accumulated more than 50 scientific research publications, clients have given high trust and affirmation to the excellent quality of Hi-Q’s functional ingredients.
 

 

Fucoidan extracted from brown algae has multiple beneficial functions. In this study, we investigated the effects of low-molecular-weight fucoidan (Oligo Fucoidan) on renal fibrosis under in vitro and in vivo diabetic conditions, and its molecular mechanisms. Advanced glycation product (AGE)-stimulated rat renal proximal tubular epithelial cells (NRK-52E) and diabetic mice induced by high-fat diet and intraperitoneal injection of streptozotocin and nicotinamide were used.

 

Oligo Fucoidan treatment significantly inhibited anti-high mobility group box 1 (HMGB1)/RAGE/ anti-nuclear factor-kappa B (NF-κB)/transforming growth factor-1 (TGF-1)/TGF-1R/Smad 2/3/fibronectin signaling pathway andHIF-1 activation inAGE-stimulated NRK-52E cells. Conversely, the expression and activity of Sirt-1; the levels of ubiquitin-specific peptidase 22 (USP22), p-AMPK, glucagon-like peptide-1 receptor (GLP-1R), and heme oxygenase-1 (HO-1); and Nrf2 activation were remarkably increased by oligo-FO in AGE-stimulated cells. However, the above effects of Oligo Fucoidan were greatly diminished by inhibiting Sirt-1, HO-1, or GLP-1R activity.

 

Similar changes of these pro-fibrotic genes in the kidney and a marked attenuation of renal injury and dysfunction were observed in Oligo Fucoidan treated diabetic mice.

 

These findings indicated that the inhibitory effects of the Oligo Fucoidan on diabetes-evoked renal fibrosis are mediated by suppressing TGF-1-activated pro-fibrogenic processes via Sirt-1, HO-1, and GLP-1R dependence. Collectively, fucoidan-containing foods or supplements may be potential agents for ameliorating renal diseases due to excessive fibrosis.

 

Mechanism of Oligo Fucoidan improves diabetes-induced renal fibrosis