2022 / 09 / 26

Exciting Breakthrough: Olaparib and Oligo-Fucoidan Combination Shows Promise in Treating Triple-Negative Breast Cancer!

Congratulations to the research team from National Health Research Institutes (NHRI, Taiwan) for a new published

Seaweed polysaccharides have been recommended as anticancer supplements and for boosting human health; however, their benefits in the treatment of triple‑negative breast cancers (TNBCs) and improving immune surveillance remain unclear. Olaparib is a first‑in‑class poly (ADP‑ribose) polymerase inhibitor. Oligo‑Fucoidan, a low‑molecular‑weight sulfated polysaccharide purified from brown seaweed (Laminaria japonica), exhibits significant bioactivities that may aid in disease management.

In this research, Macrophage polarity, clonogenic assays, cancer stemness properties, cancer cell trajectory, glucose metabolism, the TNBC 4T1 cells and a 4T1 syngeneic mouse model were used to inspect the therapeutic effects of olaparib and Oligo‑Fucoidan supplementation on TNBC aggressiveness and microenvironment.

[Results]
  1. Olaparib and Oligo‑Fucoidan cooperatively induce TNBC cell death
  2. Combined olaparib and Oligo‑Fucoidan TNBC cell growth and stemness
  3. Olaparib and Oligo‑Fucoidan cooperatively macrophage differentiation and invasion
  4. Combining Olaparib and Oligo‑Fucoidan treatment of TNBC cells further inhibits the oncogenic pathway and glucose metabolism and results in M1 macrophage polarization
  5. Oligo‑Fucoidan plus olaparib effciently inhibits postsurgical TNBC metastasis and relapse
  6. Antitumor immunity is improved by Oligo‑Fucoidan and olaparib combined therapy
Treatment was with a low molecular weight fucoidan extract (oligo fucoidan)
provided by Hi-Q Marine Biotech International Ltd., Taiwan.

[Research Article]
Chen, LM., Yang, PP., Al Haq, A.T. et al. "Oligo-Fucoidan supplementation enhances the effect of Olaparib on preventing metastasis and recurrence of triple-negative breast cancer in mice." J Biomed Sci 29, 70 (2022). https://doi.org/10.1186/s12929-022-00855-6

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