Diabetes Care

Diabetes Care
Diabetes mellitus constitutes a global health challenge with profound implications on cardiovascular, neurological, and immune functions. In recent years, attention has been directed toward bioactive compounds within seaweeds, such as Oligo Fucoidan and Fucoxanthin, due to their prospective anti-diabetic properties. Oligo Fucoidan is posited to exhibit anti-diabetic attributes encompassing antioxidant, anti-inflammatory, and hypoglycemic characteristics. Meanwhile, Fucoxanthin has shown promise in modulating lipid metabolism and enhancing insulin sensitivity.

Potential Benefits of Oligo Fucoidan and Fucoxanthin in the Management of Diabetes

  • Exhibit a-amylase and a-glucosidase inhibitory activity in vitro
  • Enhance insulin release in vitro
  • Ameliorate pancreatic β-cell death and impaired insulin synthesis
  • Improve hepatic glucose metabolism
  • Decrease in urinary sugar and on glucose
  • Significant decrease HbA1C index of Non-alcoholic Fatty Liver Disease (NAFLD) patient

Hi-Q’s Publications in Diabetes Care Research

2020 Oligo-Fucoidan Improves Diabetes-Induced Renal Fibrosis via Activation of Sirt-1, GLP-1R, and Nrf2/HO-1: An In Vitro and In Vivo Study
2020 Protective Effects of Fucoxanthin on High Glucose and 4-Hydroxynonenal (4-HNE)-Induced Injury in Human Retinal Pigment Epithelial Cells
2019 Low-Molecular-Weight Fucoidan and High Stability Fucoxanthin Decrease Serum Alanine Transaminase in Patients with Nonalcoholic Fatty Liver Disease—A Double-Blind, Randomized Controlled Trial
2017 Fucoidan Ameliorates Pancreatic β-Cell Death and Impaired Insulin Synthesis in Streptozotocin-Treated β cells and Mice via a Sirt-1-Dependent Manner
2017 Effects of Low-Molecular-Weight Fucoidan and High Stability Fucoxanthin on Glucose Homeostasis, Lipid Metabolism, and Liver Function in a Mouse Model of Type II Diabetes
2015 The Brown Seaweed Sargassum hemiphyllum Exhibits a-Amylase and a-Glucosidase Inhibitory Activity and Enhances Insulin Release In Vitro
*The Fucoidan and Fucoxanthin used in these studies was prepared by Hi-Q Marine Biotech